That's the question the Wall Street Journal asks. And while A.J. Burnett is a serious contender, the Journal concludes that Lackey would be the choice in a game you absolutely must lose.
"Lackey also has a slightly higher ratio of walks and hits to innings pitched, 1.6 vs. 1.5. He's allowing more hits per nine innings—11.6 vs. 9.1—and has given up 115 runs in 154 innings compared with Burnett's 113 runs allowed in 182.1 innings."